Clozaril - atypical antipsychotic medicine. Blocks dopamine receptors of CNS and interferes dopamine transfer in basal gangliya and in limbic part of neoncephalon. It is taken at Hypersensitivity, diseases of hemopoietic system (including in anamnesis), alcoholic and toxic psychosis, myasthenia, comas.
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Clozaril Product Description
Drug Uses
Clozaril is an atypical antipsychotic agent, providing sedative, antipsychotic, antihistamine and anticholinergic effects. Clozaril is indicated to teenagers aged 18 years and above, adults and elderly patients for treatment of:
treatment-resistant schizophrenia
psychosis during the course of Parkinson's disease
suicidal behavior in patients with schizophrenia or schizoaffective disorder
Clozaril benefits are that the drug does not virtually cause any extrapyramidal side effects such as akathisia, dystonia, bradykinesia and tremor, like other antypsyshotics do.
In contrast to classic antipsychotics, Clozaril does not increase at all or insignificantly increases the level of prolactin. Because of this, such side effects as galactorrhea, gynaecomastia and amenorrhea are normally avoided during the antipsychotic treatment with Clozaril.
To treat mental disorders, a therapeutic dose of Clozaril is recommended to be adjusted individually. At the beginning of antipsychotic therapy, low doses of Clozaril are most effective ones. For the treatment of severe mental diseases, the maximum daily Clozaril dose of 900mg can be indicated. But Clozaril doses above 450mg may significantly increase the risk of seizures and other side effects.
Missed dose
Under no circumstances should the prescribed dose of Clozaril be increased or decreased. It is stricktly not recommended to interrupt Clozaril application for more than 2 days. If you’ve forgotten to take Clozaril tablets, take the missed dose of this antipsychotic drug as soon as you remember. However, if it is nearly the time for the next prescribed dose, do not take an extra antipsychotic pill to make up the missed dose of Clozaril.
More Information
Sudden cessation of the intake of the antypsyshotic drug may cause withdrawal symptom and adverse reactions. If treatment is required to be immediately terminated (for example, in case of developing eosinophilia), gradual reduction of Clozaril dose and careful observance for the patient's mental state are recommended. Patients 60 year old and above should start the antipsychotic treatment with very low doses of Clozaril, and gradually increase the daily dose, not more than by 25mg per day.
Storage
Store the Clozaril tablets in an original container to protect them from heat and moisture. Keep Clozaril out of the reach of children at temperature not above 30°C.
Clozaril Safety Information
Warnings
During the treatment with Clozaril, severe neutropenia (abnormally low count of neutrophils) may develop in some patients, resulting in complex infection. High risk of neutropenia is observed in the first days of the antipsychotic therapy, and then is gradually decreased. Clozaril may increase the risk of seizures, so epileptic patients should take the antipsychotic with caution.
Disclaimer
Information about psychotic diseases, contained in the review of Clozaril, is
provided for the informational purposes only and should not be considered to
substitute for qualified medical care or advice of the health care provider.
The online pharmacy does not assume any liability or responsibility for damage,
arising from any use of information on atypical antipsychotic agent Clozaril.
Clozaril Side Effects
Most adverse effects of Clozaril appear only at the beginning of the antipsychotic therapy and eventually disappear. The most frequent and serious adverse effects, which Clozaril may cause include: leukocytopenia, somnolence, dizziness and psychotic disorder. Other common adverse effects of antipsychotic agent Clozaril are reported as: granulopenia, seizure triggers, cardiovascular effects, fever drowsiness/sedation, dizziness, tachyarrhythmia, constipation and ptyalism.
Septra - Sulfamethoxazole is an antibiotic that treats various types of infections caused by bacteria. The combination of sulfamethoxazole and trimethoprim is used to treat ear infection, urinary tract infection, prostate infection, bronchitis, travelers' diarrhea and pneumocystis pneumonia. The drug is available in the form of tablets, as well as in liquid form.
Seroquel - treats acute and chronic psychoses, including schizophrenia. The drug is also prescribed to patients with manic episodes associated with bipolar disorders.
An antidepressant used in cases of deep depression, panic disorders, social anxiety disorders, anxiety disorders. The mechanism of its action is based on the ability to selectively block the reuptake of serotonin by the presynaptic membrane of the neurons of the brain. Consequently, its serotonergic effect in the central nervous system that is responsible for the development of antidepressant effect, increases, which determines the effectiveness in the treatment of panic and social anxiety disorder.
An oral hypoglycemic means, which inhibiting the intestinal alpha-glycosidase, reduces the enzymatic conversion of di-, oligo - and polysaccharides to mono-saccharides, thereby reducing the absorption of glucose from the intestine and postprandial hyperglycemia. It is used to treat diabetes, of type 2 under the ineffective diet, the course of which shall not be less than 6 months, type 1diabetes within the combination therapy.
Sporanox - antifungal preparation of a wide spectrum of action. It is active against dermatophytes, yeast, yeast-like and mold fungi, causative agents of endemic mycoses. Accepted with onychomycosis, dermatomycosis, genital candidiasis, candidiasis of the oropharyngeal region, with systemic aspergillosis, candidiasis, histoplasmosis and blastomycosis.
Tetracycline has a wide range of antibacterial activity. It interferes with the formation of a complex between the transport RNA and the ribosome, which leads to a violation of protein synthesis by a microbial cell. Active in relation to most gram-positive and gram-negative bacteria, spiophets, leptospires, rickettsiaes, trachomae pathogens, ornithosis, and large viruses.
Zebeta is a beta-blocker that affects the heart and blood flow. The drug is used to treat hypertension (high blood pressure)
Crestor - is a lipid-lowering drug that reduces the elevated cholesterol concentrations in the body.
Extra Super Avana is the medicine that is aimed to treat erectile dysfunction in men. It’s a combination of Avanafil and Dapoxetine. The erection is the result of muscle relaxation and increased blood flow to men’s genitals. Strong pressure provokes strong erection that can last up to 8 hours. Men also take the drug to prevent premature ejaculation. It’s one of Viagra analogs. The difference is in their main ingredients. Thanks to that a patient has an opportunity to avoid allergy by substituting one active component with the other.
Avana - generic of Stendra, based on avanafil, whose mission is aimed at fighting impotence. It differs from the usual Viagra with minimal contraindications, longer positive outcome and the prompt onset of action. Taking one pill,the outcome begins to be felt after fifteen minutes and lasts six hours.
The medicine is used for the temporary correction of male erectile disorders. It represents the last generation of drugs for men, as it was developed less than 10 years ago and has the most modern composition than the previous tablets for treating of potency.Avanafil is an active substance of the drug.In the process of excitation in the cavernous body of the male sexual organ,, it relaxes the arteries and vessels to increase blood flow in the right places. The enzyme FDE-5 in some cases disrupts the natural process, not allowing accumulating cGMP to the required level.
Viagra with Fluoxetine - drug of new generation from the Indian pharmaceutical company Sunrise Remedies which called it Malegra FXT. It comprises two operating active agents: Sildenafil citrate and Prozac. Such combination of components effectively recovers potentiality and extends sexual intercourse by 3-4 times. But, besides, due to maintenance of Fluoxetine, Malegra FXT is a soft antidepressant and helps to remove stress and fatigue, to overcome nervousness and relax. After Malegra taking the man aquiress confidence in sexual drive, stress and anxiety disappears.
Fildena is the drug which the main component is Sildenafil Citrate. Sildenafil Citrate was invented for cough treatment but it helped to maintain an erection. That’s how the Viagra was invented. Its invention gave a start to other Sildenafil Citrate analog’s inventions like Fildena. It’s an effective medicine that copes with men’s impotence, premature ejaculation, and diminishes an enlarged prostate. Erectile dysfunction is the result of health problems, exhaustion, bad habits, drug dependence, alcohol abuse, and traumas. Fildena is one of the possible variants of ED treatment.
Zenegra is a generic Sildenafil-containing medicine intended for use in urology – for the most part in the treatment of erectile dysfunctions of different origin. The drug provides regulation of the enzymic activity of the specific phosphodiesterase and releases nitric oxide that provides the muscle-relaxing effect. The active ingredient also maintains a certain level of blood pressure in the penis, providing a proper erectile response. The usual effect lasts no less than 4 hours; however, some patients report 18 and more hours of increased sexual arousal.
Apcalis SX - Tadalafil pills, released by Ajanta in 20mg dosage. Being equal to Cialis by an outcome and the way of an action, this innovative medical mean is also directed at enhancing the hardness of the male sexual organ and reducing the period on the restoration of the male potency after the sexual act.
Antabuse - the medicine for treatment of alcoholism. The effect of medicine is implemented due to blockade of acetaldehydehydrogenaz which takes part in ethanol metabolism in consequence of which rises the level of acetaldehyde which causes a number of negative symptoms (including hot flashes, hyperemia of face, vomiting, tachycardia and increase in pressure). These effects arising after alcohol intake lead to development of cause-effect relations and rejections of alcohol intake. Thus, the patient has a conditioned-reflex disgust for a smell and taste of alcohol.
Methocarbamol – a muscle relaxant used to treat muscle spasms and pain. Its action is to block pain nerve impulses sent to the brain. The mechanism of action is not completely clear. The drug has no direct effect on skeletal muscles. It's likely that its effect is associated with sedative properties.
Dutas is a mix of two medicines: dutasteride and tamsulosin hydrochloride. The drugs have complementary mechanisms of action, due to which there is a rapid weakening of urination. It reduces the risk of retention of the urine. It is not anticipated that the pharmacodynamic reactions of a fixed dosage mix of dutasteride-tamsulosin differ from those obtained with the simultaneous use of dutasteride and tamsulosin as separate elements. Dutasteride inhibits the activity of both the 1st and 2nd type of isoenzymes. DHT is an androgen that is responsible for prostate and the increase of BPH. It inhibits the activity of adrenoreceptors.
Betapace - beta adrenoblocker, antiarrhytmic medicine. It is taken for treatment of ventricular arrhythmia, tachycardia, supraventricular arrhythmia, tachycardia at thyrotoxicosis, angina of effort, especially at combination with tachyarrhythmias, arterial hypertension, hypertrophic cardiomyopathy, prolapse of the mitral valve, prevention and treatment of myocardial infarction at stable condition of the patient.
Speman enhances male sexual performance by means of substances of vegetable origin. Extracts of seeds, stems, leaves and roots coming from nine medicinal plants are selected for their spermatogenesis-boosting properties. The drug facilitates and stimulates the process of sperm generation, increasing the mobility of spermatozoids and reducing the thickness of semen (which, consequently, improves fertilizing capabilities of sperm). Spenman decongests the prostate gland and returns its size back to unenlarged, in turn restoring both the normal urinary function and the male’s libido.
Himplasia is a unique Ayurvedic herbal drug. It helps to cope with BPH (benign prostatic hyperplasia) that causes difficulty of urine outflow, increased urge to urinate, frequent night visits to the toilet, and urine leakage. Himplasia promotes the removal of edema from the prostate and thereby improves the outflow of urine. The drug can be taken when the symptoms of BPH only begin to manifest themselves. It’s the way to reduce the risk of further development of the disease.
This medicine makes metabolism better, has cooling,febricide, urinative and nerve-strengthening properties. It is used to treat asthma, gruffness, mental disorders. It reduces anxiety in children, is used for any mental disquiet. Moreover, it is a strong blood-purifying agent with a specific effect in chronic diseases of the skin. The drug helps to create a balance between the left and right hemispheres of the brain. It is considered to be an effective means to restore hearing. .Brahmi perfectly relieves many types of headaches, normalizes cerebral circulation. It affects all tissues-elements except reproductive tissue, mainly blood and nerve tissue.
Zyprexa is an antipsychotic drug used mainly to treat severe mental conditions, most notably schizophrenia. This oral medication normalizes the balance of chemical compounds in the brain, especially when used in combination with other antipsychotics. The active ingredient, which is a ligand for serotonin and dopamine receptors, provides also a selective impact on the functioning of the limbic system. The target group of the drug is not limited to the cases with extra severity – the pills may be prescribed for people with moderate mood or nervous conditions as well.
Urispas is an oral antispasmodic drug approved to prevent bladder spasms caused by urethral catheterization, infectious and /or inflammatory diseases of the urogenital system or neurological disorders.
Differin is a white gel or cream. The drug is used to treat acne. It can also be used to combat comedones. Differin monotherapy is helpful in case of minor acne. For the treatment of severe and moderate degree of acne, the drug is used in conjunction with systemic drugs (antiandrogens, antibacterial agents). The drug is well tolerated. It rarely causes irritation, so its use is good even for those who have sensitive skin with acne. The gel is more suitable for oily skin and the cream suits better for dry skin.
Xeloda is a cytostatic drug. The drug is used for the treatment of patients with metastatic or locally advanced breast cancer, including after an ineffective chemotherapy course, which included anthracycline drugs and taxanes, and also if the patient has contraindications to anthracyclines.