Antiepileptic agent; binds to the additional subunit (a2-delta protein) of the potential-dependent Ca2 + -channels in the CNS, which promotes the manifestation of analgesic and anticonvulsant action. Reduction in the frequency of seizures begins within the first week.
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Lyrica product description
An active ingredient of Lyrica is pregabalin, which has an anticonvulsant and antiepileptic effect. Corporation Pfizer synthesized pregabalin at the end of the last century. The company initially positioned Lyrica as a modern antiepileptic agent, devoid of serious side effects typical for this class of drugs, and not causing addiction. Later it turned out that Lyrica remarkably fights anxiety and relieves depression, and the area of application has naturally expanded. The mechanism of action of Lyrica has not been completely studied yet. It is known that the substance acts on the same areas of the brain as tranquilizers, but it is not clear why it causes the physical and mental excitement not peculiar to tranquilizers. In medical circles pregabalin has established itself as a drug for the treatment of epilepsy and anxiety disorders.
Lyrica safety information
During Lyrica treatment, it is necessary to evade from driving vehicles and practicing potentially dangerous activities that require a high concentration of attention and speed of psychomotor reactions.
Women of reproductive age should use reliable methods of contraception, while treatment of Lyrica. The drug is prescribed to pregnant women only if the intended benefit to the mother outweighs the risk to the fetus.
If patients with diabetes mellitus on the background of taking Lyrica increased body weight, correction of doses of hypoglycemic medicines is necessary. Treatment of the elderly can cause dizziness and drowsiness, which increases the risk of injury in the latter.
Do not administer Lyrica to patients with hypersensitivity to pregabalinum or other components of the drug. The drug is contraindicated for children under 17, women during lactation and people with impaired lactose absorption and intolerance to lactose.
Interaction with other substances
Pregabalin is metabolized to an insignificant degree in the body and practically does not bind to plasma proteins, so the pharmacokinetic interaction of Lyric with other drugs is unlikely.
The intake of Lyrica can enhance the effects of Lorazepam and ethanol. With the simultaneous use of pregabalin and oxycodone, there is an increase in impairments of the mnestic function and the basic motor functions, which are caused by the intake of oxycodone.
The drug does not affect the pharmacological effects of other anticonvulsants, as well as the effectiveness of oral contraceptives, diuretics, oral antidiabetics, and insulin.
Lyrica side effects
In evidence-based medicine, there is no evidence of the negative effect of Lyrica on the liver. The fact is that pregabalin is not processed in the liver, therefore its toxic effect on this organ is minimal. Regarding the influence of Lyrica on sexual function - there is no reliable information about the irreversible damage to the testicles and impotence caused by Lyrica. But the negative impact of Lyrica on the kidneys does not cause any doubt. Many patients complain of swollen limbs and pain in the lumbar region during treatment with pregabalin. In addition, according to a recent experiment in mice, pregabalin and its predecessors can interfere with the development of cellular bonds in the brain, which is fraught with early dementia.
Accupril, which is quinapril, medication with hypotensive, natriuretic, cardio-protecting effect and vasodilating properties. It is used in case of an arterial hypertension (mono- or combined therapy), heart failure (combined therapy).
Super ED Trial Pack (6 Viagra + 6 Cialis + 6 Levitra) - a set sampler of Super ED Trial Pack generics which was created at numerous requests of customers. The set comprises 6 tablets (of big popularity) for solution of men's intimate problems. The set consist of: Viagra 100 mg, Cialis (20 mg) and Levitra (20 mg) that is production of well known Indian companies. All medicine of the Super ED Trial Pack set contain optimum doses of active agent and therefore you can take it for several times. Besides, it is quite possible to save money, having divided each tablet into parts.
Viagra - Active ingredient - Sildenafil, 100 mg. Effect of "Viagra" is based on significant increase of blood stream to penis. Begins to work in 30 minutes, the effect lasts for 4-5 hours. Most of men can take this generic viagra every day. Millions of men worldwide cannot be mistaken, choosing Viagra!
Cialis Professional - effective tablets for improvement of erection. They begin to work in 15 minutes from the moment of taking and actions for 36 hours. They can cause not less than 10, but no more than 16 erections. The medicine increases duration of sexual intercourse. The tablets are successfully used for reduction of time for recovery of erection after ejaculation.
Cialis Super Active is a generic drug, against erectile dysfunction, containing 20 mg of tadalafil. The tablets in this series have a gel inside. This form allows the active substance, Tadalafil, to immediately enter the blood, thus providing an immediate effect. The result from the Cialis Super Active tablets appears after 5 minutes! The action lasts for two days. The drug is safe and has virtually no contraindications.
Theo-24 Cr - medication with an active ingredient called Theophylline, the brand of Pfizer and UCB Pharma. The drug is prescribed for treatment of bronchial asthma, chronic obstructive bronchitis, pulmonary emphysema, pulmonary hypertension, pulmonary heart, edematous renal syndrome (as part of a combination therapy), nocturnal apnea.
Cymbalta drug possesses a central mechanism of suppression of a pain syndrome that first of all can be noticed at increase in a threshold of painful sensitivity at pain syndrome of neuropathic etiology.
ED Trial Pack (2 Viagra + 2 Cialis + 2 Levitra) - a trial set consists of six tablets, for those who want to understand what medicine is better for him. Includes 6 tablets (by 2 pсs.): Viagra, Cialis and Levitra. It can be taken by people older than 18 years, in case of problems in private life related to fatigue, stress, sleep debt, slow-moving way of life and abuse of addictions.
A symptomatic medication against vomiting and nausea of various origins. Used at vomiting caused by radiation therapy or cytotoxic drugs intake, hypotony and atony of the stomach and intestines, biliary dyskinesia, reflux esophagitis, flatulence, aggravation of gastric ulcer and duodenal gut, when performing contrast studies of the gastrointestinal tract. It reduces the moving activity of the esophagus, increases the tone of the lower esophageal sphincter, accelerates gastric emptying, and accelerates the movement of food through the small intestine without causing diarrhea. Stimulates the secretion of prolactin.
stimulant of the intestinal peristalsis. Motillium is assigned in cases of: distention, overeating, vomiting, heartburn, flatulence, a feeling of overflow of the stomach.
An antiarrhythmic Ia class drug, a blocker of the "fast" Na+ channels. It has a membrane stabilizing, anti-arrhythmic, hypotensive and m-anticholinergic action. In normally functioning sinus node it causes acceleration of the sinus rhythm due to the antimuscarinic effect.
Kemadrin is a medicinal substance similar in its effect to atropine; It is used to reduce tremor and rigidity of muscles in Parkinsonism.
Proscar - the drug is used to treat men’s baldness and benign prostatic hyperplasia. Inhibits the 5-alpha-reductase which converts testosterone into a more active 5-alpha-dihydrotestosterone, reduces its concentration in blood and prostate tissue.
It is a powerful tool which lowers cholesterol in the blood, strengthens blood vessels and fights parasites. Lasuna balances coronary function prevents the accumulation of cholesterol on the walls of the coronary arteries. The medicine stabilizes blood pressure levels. It regulates the level of lipids in plasma, the number of platelets in the blood, cholesterol and blood sugar and strengthens immunity. Strong antioxidant properties eliminate free radicals that cause an imbalance in the normal functioning of blood vessels, which should fully narrow and expand for their natural work.
Tadapox includes two medications combined for an even more effective approach of the problem of erectile dysfunction. The first one, Tadalafil, is a mighty restorative agent that reverses a male’s inability to achieve a satisfyingly firm erection. The second component, Dapoxetine, handles the other side of clinical impotency that shows as untimely ejaculation. Tadapox successfully manages said issues in populations of patients from 18 to 64 years of age. Its unique mix of therapeutic characteristics helps men revitalize their sexual function in a comparatively short time.
Methotrexate belongs to the group of antimetabolites with cytostatic activity. It inhibits the conversion of dihydrofolic acid into tetrahydrofolic acid. Thymidylic acid and purine synthesis are disrupted, which, in turn, suppresses DNA synthesis and cell division. The maximum absorption of the medicine is observed after 30 to 60 minutes. The drug is metabolized by enzymes of the intestinal microflora, hepatocytes, and other cells.
Voveran SR is the special formulation of Voveran, developed for the suspended release of its active ingredients and, consequently, a prolonged period of action. Apart from this feature, it has no notable characteristics differentiating it from the original medicine – an analgesic that provides satisfying results in the treatment of moderate pain syndromes. It helps with a wide range of painful conditions allowing patients to stop the pain before it grows stronger or control it in case of chronic joint diseases. In general, the new form provides better results in particular in the treatment of prolonged pain.
