Methotrexate belongs to the group of antimetabolites with cytostatic activity. It inhibits the conversion of dihydrofolic acid into tetrahydrofolic acid. Thymidylic acid and purine synthesis are disrupted, which, in turn, suppresses DNA synthesis and cell division. The maximum absorption of the medicine is observed after 30 to 60 minutes. The drug is metabolized by enzymes of the intestinal microflora, hepatocytes, and other cells.
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The pills are a component of the group of antimetabolites with cytostatic activity. They reduce the change of dihydrofolic acid in tetrahydrofolic acid.
Product Description
There are changes in Timpilo acid and purine, which in turn changes the connection of DNA and division of cells, the connection of RNA and protein. The peculiarity of the drug is in the s-phase of the cell cycle. The most sensitive to the drug are tissues with high proliferative potential (tumor tissue, bone marrow, epithelial cells, and fetal cells).
After 30 to 60 minutes, administration to the muscle has the highest concentration. The drug is well dispersed in body tissues, as well as in ascitic and pleural fluids. The kidney tissue is determined in several weeks and the tissues of the liver, for three months. When the pills are used in medium amounts, they do not penetrate the blood-brain barrier. It is metabolized by enzymes of the intestinal microflora, hepatocytes and other cells with the formation of active metabolite – pollutant (inhibitor of dihydrofolate reductase and timdelaghetto).
The terminal half-life time is dose-dependent and lasts from three to ten hours and eight to fifteen hours when using small and large doses of the drug. 90% of the received dose comes out with urine in its present form by glomerular filtration and active tubular secretion and only ten percent – within 24 hours with bile (followed by reabsorption in the intestine).
The components mostly come out with urine and its characteristics do not change. When the activity of kidney function is impaired, the elimination of methotrexate decreases speed, while its concentration in the blood plasma increases. The components could be released into breast milk.
Safety information
The pills cannot be combined with strong oxidants and acids. If they are mixed with chlorpromazine hydrochloride, droperidol, metoclopramide hydrochloride, heparin solution, prednisolone sodium phosphate and hydrochloride promethazine it would be possible to obtain its turbidity or precipitate formation.
The amount is calculated according to the weight of the person or the surface area of the skin. The tablets are effective in case of a large number of cancers as a monotherapy, and in combination with other chemotherapy drugs.
Side Effects
The pills have a negative impact on the blood system: it inhibits bone marrow function (as a result it leads to infection, sepsis, bleeding), thrombocytopenia, leukopenia, anemia, and hematoma. In the digestive system, there are such problems as gingivitis, stomatitis, pharyngitis, nausea may appear, and the patient often goes to the toilet experiencing stomach disorders. Sometimes people taking this drug feel a violation of liver function. There a liver dystrophy, erosive and ulcerative disorders of the mucous membrane of the stomach and intestines, and a liver failure may happen.
As for disorders in the nervous system, a person has a headache, dizziness, vision impairment, hemiparesis, seizures. After intrathecal administration, the pressure of cerebrospinal fluid increases. In the genitourinary system: a person starts to suffer from cystitis, azotemia, hematuria, women have the menstrual disorder, infertility, vaginal, spontaneous abortion, teratogenic effect, decreased libido, impotence, ovogenesis, spermatogenesis. Pills can lead to negative consequences of the skin such as rash, skin can itch, acne, furunculosis develops. Sometimes there is a Stevens-Johnson syndrome.
Accupril, which is quinapril, medication with hypotensive, natriuretic, cardio-protecting effect and vasodilating properties. It is used in case of an arterial hypertension (mono- or combined therapy), heart failure (combined therapy).
Super ED Trial Pack (6 Viagra + 6 Cialis + 6 Levitra) - a set sampler of Super ED Trial Pack generics which was created at numerous requests of customers. The set comprises 6 tablets (of big popularity) for solution of men's intimate problems. The set consist of: Viagra 100 mg, Cialis (20 mg) and Levitra (20 mg) that is production of well known Indian companies. All medicine of the Super ED Trial Pack set contain optimum doses of active agent and therefore you can take it for several times. Besides, it is quite possible to save money, having divided each tablet into parts.
Viagra - Active ingredient - Sildenafil, 100 mg. Effect of "Viagra" is based on significant increase of blood stream to penis. Begins to work in 30 minutes, the effect lasts for 4-5 hours. Most of men can take this generic viagra every day. Millions of men worldwide cannot be mistaken, choosing Viagra!
Cialis Professional - effective tablets for improvement of erection. They begin to work in 15 minutes from the moment of taking and actions for 36 hours. They can cause not less than 10, but no more than 16 erections. The medicine increases duration of sexual intercourse. The tablets are successfully used for reduction of time for recovery of erection after ejaculation.
Cialis Super Active is a generic drug, against erectile dysfunction, containing 20 mg of tadalafil. The tablets in this series have a gel inside. This form allows the active substance, Tadalafil, to immediately enter the blood, thus providing an immediate effect. The result from the Cialis Super Active tablets appears after 5 minutes! The action lasts for two days. The drug is safe and has virtually no contraindications.
Theo-24 Cr - medication with an active ingredient called Theophylline, the brand of Pfizer and UCB Pharma. The drug is prescribed for treatment of bronchial asthma, chronic obstructive bronchitis, pulmonary emphysema, pulmonary hypertension, pulmonary heart, edematous renal syndrome (as part of a combination therapy), nocturnal apnea.
Cymbalta drug possesses a central mechanism of suppression of a pain syndrome that first of all can be noticed at increase in a threshold of painful sensitivity at pain syndrome of neuropathic etiology.
ED Trial Pack (2 Viagra + 2 Cialis + 2 Levitra) - a trial set consists of six tablets, for those who want to understand what medicine is better for him. Includes 6 tablets (by 2 pсs.): Viagra, Cialis and Levitra. It can be taken by people older than 18 years, in case of problems in private life related to fatigue, stress, sleep debt, slow-moving way of life and abuse of addictions.
stimulant of the intestinal peristalsis. Motillium is assigned in cases of: distention, overeating, vomiting, heartburn, flatulence, a feeling of overflow of the stomach.
An antiarrhythmic Ia class drug, a blocker of the "fast" Na+ channels. It has a membrane stabilizing, anti-arrhythmic, hypotensive and m-anticholinergic action. In normally functioning sinus node it causes acceleration of the sinus rhythm due to the antimuscarinic effect.
Kemadrin is a medicinal substance similar in its effect to atropine; It is used to reduce tremor and rigidity of muscles in Parkinsonism.
Proscar - the drug is used to treat men’s baldness and benign prostatic hyperplasia. Inhibits the 5-alpha-reductase which converts testosterone into a more active 5-alpha-dihydrotestosterone, reduces its concentration in blood and prostate tissue.
It is a powerful tool which lowers cholesterol in the blood, strengthens blood vessels and fights parasites. Lasuna balances coronary function prevents the accumulation of cholesterol on the walls of the coronary arteries. The medicine stabilizes blood pressure levels. It regulates the level of lipids in plasma, the number of platelets in the blood, cholesterol and blood sugar and strengthens immunity. Strong antioxidant properties eliminate free radicals that cause an imbalance in the normal functioning of blood vessels, which should fully narrow and expand for their natural work.
Tadapox includes two medications combined for an even more effective approach of the problem of erectile dysfunction. The first one, Tadalafil, is a mighty restorative agent that reverses a male’s inability to achieve a satisfyingly firm erection. The second component, Dapoxetine, handles the other side of clinical impotency that shows as untimely ejaculation. Tadapox successfully manages said issues in populations of patients from 18 to 64 years of age. Its unique mix of therapeutic characteristics helps men revitalize their sexual function in a comparatively short time.
Voveran SR is the special formulation of Voveran, developed for the suspended release of its active ingredients and, consequently, a prolonged period of action. Apart from this feature, it has no notable characteristics differentiating it from the original medicine – an analgesic that provides satisfying results in the treatment of moderate pain syndromes. It helps with a wide range of painful conditions allowing patients to stop the pain before it grows stronger or control it in case of chronic joint diseases. In general, the new form provides better results in particular in the treatment of prolonged pain.
