Danazol is used in endometriosis (with concomitant infertility), benign neoplasms of the breast (fibrocystic mastopathy), primary menorrhagia, premenstrual syndrome, primary premature puberty, gynecomastia.
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Danazol product description
Danazol belongs to the group of drugs intended for the treatment of sexual/urinary diseases and sex hormone preparations.
The composition includes Danazol - a means that modulates the work of the reproductive system.
Danazol inhibits the production of gonadotropic hormones (follicle-stimulating and luteotropic) by the pituitary gland. Gonadotropin deficiency slows the work of ovaries and ovulation, reduces the concentration of estrogen in the body, endometrial atrophy occurs. With endometriosis, the medication damages normal and ectopic areas; reduces the area of damaged areas and reduces pain. Under the influence of the drug, proliferation of erythrocytes, the development of immunoglobulins and autoantibodies is reduced. In case of mastopathy with fibrocystic formations, Danazol helps to reduce the size of the nodes or complete their dissolution with the elimination of pain and discomfort. By increasing the content of the C1-esterase inhibitor, Danazol helps with hereditary angioedema. Pharmacological action of the drug is reversible. In case of using the high tolerated doses, Danazol may have a weak androgenic effect and may be accompanied by anabolism.
Danazol safety information
Danazol is forbidden for people with allergies to danazol and intolerance to other capsule components. The drug is contraindicated if the patient has porphyria, glucose-galactose malabsorption, heart failure, kidney and liver, bleeding from the genital organs without establishing the cause, acute thrombosis and thromboembolic disease, lactose deficiency. Danazol is not allowed for oncological patients with androgen-dependent tumors, breast cancer. Capsules are not allowed for children under 18 years of age. It is possible to treat Danazol with liver, kidney, heart and vascular diseases, diabetes mellitus, hypertension, migraine, polycythemia, epilepsy, dyslipidemia, with persistent androgenic reactions to sex hormone therapy in the anamnesis, with caution. Caution should be taken while consuming medication in case of violation of plasma mechanisms of hemostasis and any other conditions that can worsen if the water-electrolyte balance is disturbed. It is forbidden to use Danazol for the medical care of pregnant and lactating women. During therapy, non-hormonal methods of contraception should be used.
Danazol side effects
Often, with the use of capsules, some patients may experience the following adverse reactions: seborrhea, acne, emotional lability, weight gain, hirsutism, alopecia, voice coarsening, increased appetite, menstrual irregularity, mucous hemorrhagic discharge between menstruation, amenorrhea, vaginal dryness, anxiety, changes in libido, irritation of the vaginal mucosa , hot flashes, headache, hypersensitivity to insulin, decreased glucose tolerance, increased HDL concentration, decreased thyroxine content, rash, fever, facial edema and Charter, photosensitivity, pain in the back, extremities and joints, muscle spasms, tremors, fasciculation, depression, nervousness, nausea. Infrequent use of Danazol can cause a decrease in the mammary glands, urticaria, an increase in the activity of serum transaminases. Rarely, tachycardia, pancreatitis, visual impairment, clitoral hypertrophy, fluid retention in the body, decreased spermatogenesis, inflammation of the erythematous nodes, leukopenia, skin pigmentation disorder, exfoliative dermatitis, exudative erythema multiforme, cholestatic jaundice, hypertension, palpitation, thrombotic complications, an increase in the content of red blood cells and platelets, dizziness, polycythemia, increased intracranial pressure, thrombocytopenic benign adenoma of the liver, weakness. Very rarely, Danazol therapy provokes myocardial infarction, epilepsy weighting, migraine attacks, eosinophilia, splenic peliosis, malignant tumor and liver hemorrhage, hematuria, epigastric pain, carpal tunnel syndrome, interstitial pneumonia.
Accupril, which is quinapril, medication with hypotensive, natriuretic, cardio-protecting effect and vasodilating properties. It is used in case of an arterial hypertension (mono- or combined therapy), heart failure (combined therapy).
Theo-24 Cr - medication with an active ingredient called Theophylline, the brand of Pfizer and UCB Pharma. The drug is prescribed for treatment of bronchial asthma, chronic obstructive bronchitis, pulmonary emphysema, pulmonary hypertension, pulmonary heart, edematous renal syndrome (as part of a combination therapy), nocturnal apnea.
Cymbalta drug possesses a central mechanism of suppression of a pain syndrome that first of all can be noticed at increase in a threshold of painful sensitivity at pain syndrome of neuropathic etiology.
Fulvicin - the antifungal antibiotic, which is taken at mycosis of skin, hair and nails (favus, trichophytosis, microsporia of a pilar part of the head, microsporia of smooth skin, dermatomycosis of beard and moustaches, epidermophitia of smooth skin, inguinal epidermophitia, onychomycoses). It is effective concerning fungus of the sort Trichophyton, Microsporum, Epydermophyton, Achorionum; causes disturbance of the structure of a mitotic spindle and synthesis of a cell wall at chitin fungus, suppresses division of fungal cells in metaphase and synthesis of protein because of disruption of linking with template-RNA.
Famvir - antiviral medicine which is taken for prevention and treatment of herpes at primary infection, post-herpetic neuralgia, recurrent genital herpes. Pro-medicine; represents a 6-deoxysidiacetil analog of active antiviral agent of a penciclovir.
Avalide is an effective medicine which aim is to lower the blood pressure. Hypertension provokes serious diseases as strokes, heart attack, and problems with the kidney. An angiotensin receptor blocker and diuretic are the basic components of the drug. The first one relaxes the walls of the blood vessels letting the blood move freely without the pressure. The second component stimulates urination so that a patient can get rid of extra salt and water which also provoke high blood pressure.
ED Trial Pack (2 Viagra + 2 Cialis + 2 Levitra) - a trial set consists of six tablets, for those who want to understand what medicine is better for him. Includes 6 tablets (by 2 pсs.): Viagra, Cialis and Levitra. It can be taken by people older than 18 years, in case of problems in private life related to fatigue, stress, sleep debt, slow-moving way of life and abuse of addictions.
A symptomatic medication against vomiting and nausea of various origins. Used at vomiting caused by radiation therapy or cytotoxic drugs intake, hypotony and atony of the stomach and intestines, biliary dyskinesia, reflux esophagitis, flatulence, aggravation of gastric ulcer and duodenal gut, when performing contrast studies of the gastrointestinal tract. It reduces the moving activity of the esophagus, increases the tone of the lower esophageal sphincter, accelerates gastric emptying, and accelerates the movement of food through the small intestine without causing diarrhea. Stimulates the secretion of prolactin.
stimulant of the intestinal peristalsis. Motillium is assigned in cases of: distention, overeating, vomiting, heartburn, flatulence, a feeling of overflow of the stomach.
Antiepileptic agent; binds to the additional subunit (a2-delta protein) of the potential-dependent Ca2 + -channels in the CNS, which promotes the manifestation of analgesic and anticonvulsant action. Reduction in the frequency of seizures begins within the first week.
An antiarrhythmic Ia class drug, a blocker of the "fast" Na+ channels. It has a membrane stabilizing, anti-arrhythmic, hypotensive and m-anticholinergic action. In normally functioning sinus node it causes acceleration of the sinus rhythm due to the antimuscarinic effect.
The drug dilates coronary vessels (mostly arterioles) and causes a significant increase in volumetric blood flow velocity. Increases the content of oxygen in venous blood of coronary sinus and its absorption by myocardium. Promotes the development of collateral coronary circulation, reduction in a systemic vascular resistance, improves microcirculation, has angioprotective action.
Kemadrin is a medicinal substance similar in its effect to atropine; It is used to reduce tremor and rigidity of muscles in Parkinsonism.
Proscar - the drug is used to treat men’s baldness and benign prostatic hyperplasia. Inhibits the 5-alpha-reductase which converts testosterone into a more active 5-alpha-dihydrotestosterone, reduces its concentration in blood and prostate tissue.
Tenorminis a cardioselective beta-adrenoblocker. It is based on a substance called Atenolol, which blocks nerve impulses, which leads to a decrease in the frequency and strength of the heartbeat. Atenolol has antihypertensive (lowers pressure), antianginal (eliminates the symptoms of myocardial ischemia) and antiarrhythmic (eliminates heart rhythm disturbances) by action.
It is a powerful tool which lowers cholesterol in the blood, strengthens blood vessels and fights parasites. Lasuna balances coronary function prevents the accumulation of cholesterol on the walls of the coronary arteries. The medicine stabilizes blood pressure levels. It regulates the level of lipids in plasma, the number of platelets in the blood, cholesterol and blood sugar and strengthens immunity. Strong antioxidant properties eliminate free radicals that cause an imbalance in the normal functioning of blood vessels, which should fully narrow and expand for their natural work.
Tadapox includes two medications combined for an even more effective approach of the problem of erectile dysfunction. The first one, Tadalafil, is a mighty restorative agent that reverses a male’s inability to achieve a satisfyingly firm erection. The second component, Dapoxetine, handles the other side of clinical impotency that shows as untimely ejaculation. Tadapox successfully manages said issues in populations of patients from 18 to 64 years of age. Its unique mix of therapeutic characteristics helps men revitalize their sexual function in a comparatively short time.
Methotrexate belongs to the group of antimetabolites with cytostatic activity. It inhibits the conversion of dihydrofolic acid into tetrahydrofolic acid. Thymidylic acid and purine synthesis are disrupted, which, in turn, suppresses DNA synthesis and cell division. The maximum absorption of the medicine is observed after 30 to 60 minutes. The drug is metabolized by enzymes of the intestinal microflora, hepatocytes, and other cells.
Voveran SR is the special formulation of Voveran, developed for the suspended release of its active ingredients and, consequently, a prolonged period of action. Apart from this feature, it has no notable characteristics differentiating it from the original medicine – an analgesic that provides satisfying results in the treatment of moderate pain syndromes. It helps with a wide range of painful conditions allowing patients to stop the pain before it grows stronger or control it in case of chronic joint diseases. In general, the new form provides better results in particular in the treatment of prolonged pain.