The drug is an inhibitor of the enzyme peptidyl. It inhibits the angiotensin-converting enzyme, which catalyzes the conversion of angiotensin I to vasoconstrictor peptide angiotensin II. Angiotensin II also stimulates the secretion of aldosterone by the adrenal cortex. Inhibition of ACE leads to reduced concentrations of angiotensin II, resulting in low aldosterone secretion. The decrease in the latter leads to an increase in the content of potassium in the blood serum. Since the mechanism is believed to be based on the inhibition of the renin-angiotensin-aldosterone system, it reduces blood pressure even in patients with hypertension with low renin levels.
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The tablets are aimed at normalizing blood plasma composition. They reduce triglyceride content and increase apolipoprotein AI. The medicine inhibits peripheral lipolysis, helps to remove free fatty acids from the liver and blocks the inclusion of acyl in synthesized triglycerides. They lower its levels in the liver.
Product Description
The pills make faster turnover and removal of cholesterol and promote its excretion from the body. The components of the remedy are well absorbed if you take it inside. Absorption occurs one and a half hours after administration. The tablets are low-toxic and they make a concentration of lipids in the blood lower. They decrease lipoprotein in patients with hypertriglyceridemia and increase the number of triglycerides in the blood.
The drug does not react to the treatment by diet or other hypolipidemic agents. It increases the concentration of HDL (high-density lipoproteins).The medicine is prescribed for patients with hypertriglyceridemia if they are resistant to a therapeutic diet or other related means. If one has hyperchylomicronemia (increased blood levels of chylomicrons /neutral fat particles with a diameter of 1 micron due to family deficiency of lipoprotein lipase (an enzyme that destroys lipoproteins), the drug will be ineffective.
Safety Information
It is necessary to check the number of lipids in the blood during the treatment. If the effectiveness of the drugs is not manifested within three months, then the therapy should be stopped. It is also necessary to follow the diet. In long-term care one needs a constant control of the peripheral blood and as well as of indications of the functions of the liver. If there are significant changes in the liver, it is necessary to stop treatment until the normal findings.
If you miss a dose of pills you need to take the next one as soon as possible and double it twice. Sometimes the pain in the muscles may appear and in this case, it is necessary to exclude the presence of myositis. If it is found in the body, the treatment will be canceled. One should stop taking pills if cholelithiasis is detected. The tablets are incompatible with lovastatin because there may be a severe form of myopathy or liver failure. The drug enhances the effect of indirect anticoagulants and oral hypoglycemic drugs.
While taking the drugs, the risk of violations of fat metabolism increases. Adult patients have prescribed pills of 0.45 grams twice a day. It is usually taken in the morning 30 minutes before breakfast or in the evening and 30 minutes before dinner. The highest therapeutic effect is observed after three or four weeks after the first administration of the tablet.
Side Effects
The medicine has an adverse reaction on the nervous system. One may feel the following symptoms:
- dizziness;
- a headache;
- excessive fatigue;
- drowsiness;
- depression.
Sometimes there is dysfunction in the digestive system, such as dry mouth, low appetite, nausea, vomiting, heartburn, constipation or diarrhea. On the part of the human motor system can there are:
- Myasthenia gravis;
- Myalgia;
- Arthralgia;
- Rhabdomyolysis.
In the genitourinary system, there are decreases in potency and libido. Sometimes there are allergic reactions that appear in the skin, for example, rash or dermatitis. Among other sideway actions, one can identify visual impairment, hypokalemia, alopecia, synovitis.
Ventolin is a medicament for eliminating asthma attacks (bronchial) and other reversible diseases with bronchial obstruction.
The main active substance is salbutamol.
Pamelor is a tricyclic antidepressant (TCA, tricyclic antidepressants) of the second generation. It is used in the treatment of some major depressive disorder and nocturnal enuresis (bedwetting) in children. In addition, the drug is sometimes used for the treatment of chronic diseases such as chronic fatigue syndrome, chronic pain and migraine, and the lability in certain neurological diseases.
Glycomet is a drug that is also called Biguanide. It’s a hypoglycemic agent that reduces the concentration of glucose in the blood by suppressing gluconeogenesis in the liver, reducing the absorption of glucose from the digestive tract, and increasing its utilization in tissues in patients with diabetes mellitus. The drug reduces the concentration of Thyroglobulin, cholesterol, and LDL (determined on an empty stomach) in the blood serum and does not change the concentration of lipoproteins of other densities. Glycomet stabilizes or reduces body weight. The pills don’t cause hypoglycemic reactions and improve the fibrinolytic properties of the blood.
Zyvox is a synthetic medicine with the increased antibacterial effectiveness. It is mostly used in the treatment of pulmonary and skin diseases caused by a wide range of Gram-positive species. In current medicinal practice, Zyvox often plays a role of the drug of last resort, since it is intended for use in people suffering from multidrug-resistant infections. The extremely high efficiency of this medicine makes it a popular choice in the treatment of severe bacterial infections and simultaneously limits its use against low-hazard infections in order to avoid propagation of resistant microorganisms.
Ceftin - the antibiotic cephalosporin, is prescribed for treatment of Bacterial infections caused by sensitive microorganisms: respiratory diseases (bronchitis, pneumonia, abscess of lungs, a pleura empyema, etc.), ENT organs (sinusitis, tonsillitis, pharyngitis, otitis, etc.), urinary tract (pyelonephritis, cystitis, asymptomatic bacteriuria, gonorrhea, etc.), skin and soft tissues (face, pyoderma, impetigo, furunculosis, phlegmon, a wound fever, diamond-skin disease, etc.), bones and joints (osteomyelitis, septic arthritis, etc.), small pelvis (endometritis, adnexitis, cervicitis), sepsis, meningitis, Lyme desease (borreliosis), prevention of infectious complications at operations on Thoracic organs, abdominal cavity, pelvis, joints inc. at operations.
Chloromycetin - the Antibiotic of a broad spectrum of activity. The mechanism of antimicrobic action is connected with disturbance of protein synthesis of microorganisms. It has bacteriostatic action. It is active concerning gram-positive bacteria. Chloromycetin is active concerning the strains steady against penicillin, streptomycin, streptocides.
Suprax - is a semisynthetic antibiotic of the group of the third generation cephalosporins for oral administration. It has bactericidal action. The drug is formed on the basis of cefiximum under the name Suprax given by such companies:Wyeth, Elder Pharmaceuticals, Fujisawa, Gedeon Richter, Hikma Pharmaceuticals, Lederle, Lupin Pharmaceuticals, Sanofi-Aventis.
Zocor is indicated to reduce mortality due to coronary artery disease. It is prescribed for the reduction of risk of serious vascular and coronary complications: non-fatal myocardial infarction, coronary death, stroke; revascularization operations. Designed to reduce the risk of the need for coronary blood flow restoration; rot reduce the risk of the need for surgical intervention to restore peripheral blood flow and other types of non-coronary revascularization; to reduce the risk of hospitalization in connection with attacks of angina pectoris; to decrease in the elevated level of total cholesterol, LDL cholesterol, triglycerides. apolipoprotein B; for increasing HDL cholesterol in patients with primary hypercholesterolemia, including heterozygous familial hypercholesterolemia.
Brand Viagra - a drug from Pfizer, with a basic chemical called Sildenafil Citrate, is a first developed pharmaceutical to cure the difficulties with erection. It functions approximately within 4-5 hours, must be taken an hour prior to sex.
Levitra with Dapoxetine - a mixture of Levitra 20 mg with Dapoxetine 60 mg, often called Super Vilitra, which principal parts dilate the vessels, influence on the tissues of the small pelvis, better the hardness of the penis muscles, making erection more real and become the obstacle to a rapid ejaculation.
Levitra - the main component - the active agent Vardenafil which promotes strengthening of blood circulation in generative organs of men. It allows to reach a high level erection at sexual stimulation, and also to increase sensitivity of head of a penis and to make sexual intercourse longer and more pleasant. The main feature of a drug Levitra - quickness of effect, duration of impact on an organism up to 12 hours and a very small number of side effects.
Fights diarrhea (acute and chronic of various genesis: allergic, emotional, drug, radiation, with a change in diet and quality of food, in violation of metabolism and absorption), used for regulation of stool in patients with ileostomy. Loperamide (the effective ingredient of Imodium) reduces the tone and motility of the smooth muscles of the intestine. Slows down the peristalsis and increases the transit time of intestinal contents. Increases the tone of the anal sphincter, promotes retention of fecal masses and reduced urge to defecate. The effect develops quickly and lasts for 4-6 hours.
Sinemet - a combined remedy based on Levodopum + Carbidopum. In the treatment of Parkinson's syndrome and disease, Sinemet proved to be one of the most effective drug. The reviews are mostly positive, because it allows to reduce "inhibition" in patients who have been treated with other medications. For each patient, the dosage is selected individually, together with the frequency of admission.
Aggrenox - the combined antiplatelet agent. There are two active ingredients - acetilsalicylic acid and dipiridamol. Action of such combination is caused by different biochemical mechanisms. Aggrenox is prescribed for secondary prevention of ischemic stroke which proceeds as thrombosis. Medicine is also effective for prevention of transitory ischaemic attack.
Topamax - the remedy with an active ingredient: topiramate, it is used as a monotherapy for the treatment of adults and children 6 years of age with partial attacks with or without secondary generalized seizures and primary generalized tonic-clonic seizures; as an adjunct therapy for the treatment of adults and children 2 years of age with partial attacks with or without secondary generalized seizures or primary generalized tonic-clonic seizures and the treatment of attacks associated with Lennox-Gasto syndrome; to prevent migraine attacks in adults, after careful evaluation of alternative treatment options. Topiramate is not recommended for the treatment of acute conditions.
Zerit - treatment of infection caused by HIV, with severe clinical manifestations and ineffectiveness or intolerance of zidovudine, and other antiretroviral drugs. The nucleoside analogue of thymidine is phosphorylated by cellular enzymes to its active form - stavudine triphosphate. Suppresses reverse transcriptase of HIV, cellular DNA polymerases (beta and gamma), inhibits the synthesis of viral and mitochondrial DNA. It is active against HIV-1.
Vasotec- an antihypertensive drug based on the action of the active ingredient Enalapril, whose mechanism of action is associated with inhibition of the activity of the angiotensin-converting enzyme, leading to a decrease in the formation of the vasoconstrictor factor - angiotensin II and simultaneously to the activation of the formation of kinin and prostacyclin possessing a vasodilating action.
Hytrin refers to the group of pharmaceutical products intended to cure the sexual/urinary maladies and sex hormone medical preparations. Its composition includes Terazozin - a medical mean for the normalization of the prostate gland in benign hypertrophy.
Voltaren has various forms of release but the topical gel is the most popular. The use of Voltaren gel leads to a reduction in edema of the tissues, pain and a reduction in the recovery time of the functions of damaged joints, ligaments, tendons and muscles.
The drug reduces the severity of acute pain an hour after its application. Due to the water-alcohol basis, this topical remedy also has a local anesthetic and cooling effect.
Calcium channel blocker, a derivative of 1,4-dihydropyridine, has a predominantly cerebrovasculative and antiischemic action. Prescribed for the prevention and treatment of brain ischemia on the background of subarachnoid hemorrhage caused by aneurysm rupture, expressed by brain disfunction in the elderly patients. It can prevent or eliminate spasm of vessels caused by various vasoconstrictor drugs. Improves stability and functional capacity of neurons.
Toradol - tablets containing 5 and 10 mg of ketorolac tromethamine as an active substance. It has a pronounced analgesic, as well as antipyretic and anti-inflammatory action, the mechanism of which is associated with inhibition of the synthesis of prostaglandins. Suppresses the aggregation of platelets.
Zanaflex (tizanidine) - the drug with an antispastic effect in increased muscle tone, relieves spasms and clonic convulsions.
Assign with painful muscular spasms associated with static and functional spine lesions (cervical and lumbar syndrome), and after surgery for a herniated disc or osteoarthritis of the thigh, as well as for spasms and pain due to multiple sclerosis, chronic myelopathy, degenerative diseases of the spinal cord brain, stroke, with cramps of central origin.
Gyne-Lotrimin - antifungal medicine from group of derivatives of imidazole for external and local (intravaginal) use, reduces synthesis of ergosterol which is a component of a cellular membrane of a microbic wall and leads to change of its structure and properties.